I used ebookers to planify a 4 flights trip over the United States. I found very cheap flights with a lot of possibilities to tune the hours of the flights. The search view allowed me to easily change the days of flights to find something cheaper or with more convenient hours. At the end, I ended up with a very cheap set of flights that was easy to booking and with all the necessary information.
The only drawback I have is that the number of multi-city flights is limited to 4.
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